منابع مشابه
An unresolved LINC in the nuclear envelope.
The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architec...
متن کاملExploring the LINC to nuclear envelope spacing
L INC complexes do not maintain the space between nuclear membranes, except in cells exposed to mechanical stress, Cain et al. reveal. SUN proteins in the inner nuclear membrane and KASH proteins in the outer nuclear membrane form LINC complexes that regulate multiple processes by connecting the nucleoskeleton to the cytoskeleton. LINC complexes are also thought to maintain a uniform gap of ~50...
متن کاملNuclear envelopathies: a complex LINC between nuclear envelope and pathology
Since the identification of the first disease causing mutation in the gene coding for emerin, a transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants have been found in genes encoding for nuclear envelope components. These proteins can be part of the inner nuclear membrane (INM), such as emerin or SUN proteins, outer nuclear membrane (ONM), such as Nesprins, or...
متن کاملOuter nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture
Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one, Kuduk (Kud), which can reside at the outer nuclear membrane and is required for the development of Drosophila melanogaster ovarian follicles and NE morpho...
متن کاملNuclear Envelope Retention of LINC Complexes Is Promoted by SUN-1 Oligomerization in the Caenorhabditis elegans Germ Line
SUN (Sad1 and UNC-84) and KASH (Klarsicht, ANC-1, and Syne homology) proteins are constituents of the inner and outer nuclear membranes. They interact in the perinuclear space via C-terminal SUN-KASH domains to form the linker of nucleoskeleton and cytoskeleton (LINC) complex thereby bridging the nuclear envelope. LINC complexes mediate numerous biological processes by connecting chromatin with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Bioengineering
سال: 2016
ISSN: 1865-5025,1865-5033
DOI: 10.1007/s12195-016-0431-1